Classification of biologically active defective viruses
1. Interference-defective virus, also known as defective interfering particles (DI particles), is a type of subgenome deletion mutant produced during virus replication and must rely on its homologous complete virus to replicate. The DI genome is smaller than its complete virus and replicates more quickly, and it tends to dominate when co-infected with its complete virus, thereby interfering with its replication. 2. Satellite virus A virus that is parasitic on the gene product of a helper virus that has nothing to do with it. Genome defects must rely on helper viruses to replicate medicine , The genome rarely has homology. Satellite viruses are now classified as satellites of subviral factors. 3. Conditional defect virus It is a type of viral conditional lethal mutant that has a mutation in its genome. It can reproduce normally under allowed conditions, cause abortion infection under restricted conditions, and can also interfere with wild-type virus replication. 4. Integrated viral genome After some mild bacteriophages and tumor viruses infect the host cell, the viral genome is integrated into the host chromosome and is transmitted to the progeny cells as the cell divides. Except for the defective exogenous RNA tumor virus, the virus-integrated cells do not produce infectious virus. Only under certain conditions, the viral genome integrated into the host chromosome can be transferred into the replication cycle and produce infectious virus particles. Examination technician examinations generally do not involve much, just for understanding.
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