Research paper published by Shanghai Institute of Pharmaceutical Sciences on mass spectrometry ionization theory
LC-MS / MS combined technology is an important detection technology for drug analysis and pharmacokinetic research. The analysis of trace Chinese medicine multi-components in biological samples is also becoming more and more extensive. Li Chuan's research group of Shanghai Institute of Materia Medica, Chinese Academy of Sciences has been committed to the technological innovation of multi-component analysis of trace Chinese medicine, thereby promoting the development of Chinese medicine analysis and pharmacokinetics of Chinese medicine. Recently, Li Chuan's research group Niu Wei and Zhu Xiaohong and others published the research results of the effect of low concentration electrolyte on the analysis of eight ginkgo components lactone and flavonoid compounds in different ion sources in the Journal of Mass Spectrometry The ionization mechanism of mass spectrometry is described. In this study, by adding electrolytes to the mobile phase, the differences in the response of ginkgo flavonoids and lactones on API 4000 Qtrap and TSQ Quantum ion sources were compared. With the addition of low concentration electrolyte, the response of most compounds to the two ion sources is increased due to reasons such as the conductivity of the electrospray droplets and the increase in surface area / volume ratio, and the matrix effect is weakened. But as the concentration increases, the two types of compounds behave significantly differently on the two ion sources. By lowering the temperature of the atomizing gas and comparing the strength of the matrix effect, the researchers revealed the reason for the difference. After the addition of the electrolyte, the reduction of the droplet radius helps to form gaseous ions, but the droplet shrinkage is supplemented by the high-temperature atomizing gas. Too fast, reducing the time of compound ion distribution to the droplet surface. At the same time, the increase in the concentration of electrolyte ions in the droplets makes the gradually shrinking droplets tend to crowd, hinder the migration of compound ions to the droplet surface, and ultimately leads to a decrease in the response of the compound. The researchers thus concluded that the application of the liquid electrolyte needs to match the mass spectrometer ion spray conditions. The research results provide ideas and guidance for the in vivo analysis of multi-component traditional Chinese medicine. In the early stage of Li Chuan's research group, technological innovations such as low-concentration electrolyte effects and pulsed gradient chromatography helped to meet the challenges of drug quality analysis in trace amounts in vivo. Seven related articles have been published in SCI magazines such as Chromatography A. This research work was supported by the National Science and Technology Major Project "Major New Drug Creation" (2009ZX09034-002) and the National Natural Science Foundation (3077277). Ceramic Ionic Hair Straightener Brush has an impressive twelve temperature settings, giving you maximum customization for your hair straightening. It features an eight foot power cord with a swivel joiner that will allow you to rotate the brush 360-degrees. It also has a hanging hook that will allow you to store it out of the way, yet readily accessible at all times. Straightening Brush,Best Straightening Brush,Ceramic Straightening Brush,Heated Straightening Brush Ningbo Meirou Electric Appliance Co.,Ltd. , https://www.mrairblower.com