Pharmacokinetics of Leonuridine in Rats

【Abstract】 Objective To study the pharmacokinetics of Leonurine in rats. Methods HPLC was established for the determination of Leonurine in rat plasma. The chromatographic conditions were Alltech C18 column (250mm×4.6mm, 5μm). The mobile phase was methanol aqueous diethylamine (75∶2 5:0). .75), flow rate: 1 mL·min-1, detection wavelength: 2 82 nm. Intravenous injection of Leonuridine solution from the femoral vein was used to determine the plasma concentrations at different times. The 3P87 pharmacokinetic program was used to fit the blood drug concentration time data. RESULTS: The main pharmacokinetic parameters of rats after intravenous administration of Leonuridine were: VC (0.353 ± 0.023) L kg-1, CL (0.451 ± 0.074) mg. ·h-1·kg-1,K12 (7.787± 2

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